All links on this page provide information on aluminum in vaccines:
- Aluminium in brain tissue in familial Alzheimer’s disease
The genetic predispositions which describe a diagnosis of familial Alzheimer’s disease can be considered as cornerstones of the amyloid cascade hypothesis. Essentially they place the expression and metabolism of the amyloid precursor protein as the main tenet of disease aetiology. However, we do not know the cause of Alzheimer’s disease and environmental factors may yet be shown to contribute towards its onset and progression. One such environmental factor is human exposure to aluminium and aluminium has been shown to be present in brain tissue in sporadic Alzheimer’s disease.
Source: Science Direct - The toxicology of aluminum in the brain: A review
Aluminum is environmentally ubiquitous, providing human exposure. Usual human exposure is primarily dietary. The potential for significant Al absorption from the nasal cavity and direct distribution into the brain should be further investigated.
Source: College of Pharmacy and Graduate Center for Toxicology, University of Kentucky Medical Center - Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?
The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of neural aberrations associated with higher cognitive functions. Aluminum (Al) is the most abundant neurotoxic metal on earth, widely bioavailable to humans and repeatedly shown to accumulate in AD-susceptible neuronal foci.
Source: Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada - Biopersistence and brain translocation of aluminum adjuvants of vaccines
Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition.
Source: Faculté de Médecine and Faculté des Sciences et Technologie, Créteil , France - Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses
Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans. The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease (AD) has been suggested.
Source: Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Miyazaki, Japan - How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale
Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes.
Source: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada - Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice
Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny. Among the vaccine's potentially toxic components are the adjuvants aluminum hydroxide and squalene. To examine whether these compounds might contribute to neuronal deficits associated with GWI, an animal model for examining the potential neurological impact of aluminum hydroxide, squalene, or aluminum hydroxide combined with squalene was developed.
Source: Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada - Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells
Although aluminum (Al), a known environmental toxin, has been implicated in a variety of neurological disorders, the molecular mechanism responsible for these conditions is not fully understood. In this report, we demonstrate the ability of Al to trigger mitochondrial dysfunction and ineffective adenosine triphosphate (ATP) production.
Source: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada - Exposure to mercury and aluminum in early life: developmental vulnerability as a modifying factor in neurologic and immunologic effects
Currently, ethylmercury (EtHg) and adjuvant-Al are the dominating interventional exposures encountered by fetuses, newborns, and infants due to immunization with Thimerosal-containing vaccines (TCVs). Despite their long use as active agents of medicines and fungicides, the safety levels of these substances have never been determined, either for animals or for adult humans—much less for fetuses, newborns, infants, and children.
Source: Department of Nutrition, Faculty of Health Sciences, Universidade de Brasilia, Brazil - Aluminium in brain tissue in autism
Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder.
Source: The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, United Kingdom - Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's disease
There has been a plausible link between human exposure to aluminum and Alzheimer's disease for several decades. We contend that the only direct and ethically acceptable experimental test of the 'aluminum hypothesis', which would provide unequivocal data specific to the link, is to test the null hypothesis that a reduction in the body burden of aluminum to its lowest practical limit would have no influence upon the incidence, progression, or severity of Alzheimer's disease.
Source: The Birchall Centre, Lennard-Jones Laboratories, Keele University, Stoke-on-Trent, Staffordshire, UK - Biopersistence and brain translocation of aluminum adjuvants of vaccines
Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition.
Source: Faculté de Médecine and Faculté des Sciences et Technologie, Université Paris Est-Créteil, Créteil, France - Studies Link Heavy Metals to the Explosion of Neurodevelopmental Disorders and Declining IQ in American Children
A “silent pandemic of neurodevelopmental toxicity” is disabling a generation of children around the world. This is the verdict of neurology experts Philippe Grandjean and Philip Landrigan in a 2014 report in Lancet Neurology. The staggering tsunami of developmental disabilities now affects at least one in six children in the U.S. and millions more worldwide. Two new studies suggest that the most common of these illnesses—autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and tics—are related to each other and may share common causation. The culprit? Environmental toxins, particularly heavy metals.
Source: Epoch Times - High levels of aluminum in 80 percent of people tested for toxicity
Aluminum, which performs no identifiable function in the human body, is not a nutrient. Yet, most of us consume this neurotoxic substance – or inhale its fumes, or apply it to our skin – on a daily basis. According to Analytical Research Labs, a whopping 80 percent of people tested have excessively high aluminum levels – a disturbing statistic, given that metal toxicities are associated with a wide range of chronic disease conditions.
Source: Natural Health 365 - Insight into the cellular fate and toxicity of aluminum adjuvants used in clinically approved human vaccinations
Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post vaccination.
Source: Matthew Mold, Emma Shardlow & Christopher Exley - Hepatic response to aluminum toxicity: dyslipidemia and liver diseases
In the present review, we describe how the use of a systems biology approach in cultured hepatoblastoma cells (HepG2) allowed the identification of the molecular targets of Al toxicity.
Source: Laurentian University, Department of Chemistry and Biochemistry, Canada - CDC Confirms Aluminum In Vaccine Never Tested
CDC confirms the vaccine schedule and injected aluminum has never been tested
Source: Centers for Disease Control - Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity. In some developed countries, by the time children are 4 to 6 years old, they will have received a total of 126 antigenic compounds along with high amounts of aluminum (Al) adjuvants through routine vaccinations.
Source: Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada - How Aluminum affects Neurological Health
This article will tell you how to recognize the symptoms of aluminum toxicity. Aluminum toxicity is something I am very concerned about. In 2004, a large portion of the mercury that was previously used in childhood vaccines was removed from those sold and administered in the United States.
Source: Vax Truth - Human Studies that indicate vaccine-autism link
“It does not take a stretch of the imagination to see how the immune system may learn to respond to self-antigens that resemble those in pathogens, when adjuvants like aluminum so effectively activate the adaptive immune response. This topic has been extensively studied by Yehudah and colleagues (e.g., Agmon et al., 2009; Rinaldi et al., 2014). But then one does not need a stretch of the imagination when we have the bulk of science indicating that as more vaccines have been added to the pediatric schedule, we have been putting more and more immunostimulants into the bodies of our youth, inducing increasing numbers of autoimmune reactions and stronger innate autoimmunity, especially immunocytotoxicity, in human studies.
Source: James Lyons Weiler - Vaccine Aluminum Travels Into The Brain
This article is concerned with the nanoparticulate form of aluminum in vaccines, and the unique way that aluminum adjuvant nanoparticles (AANs) are transported around the body. The movement of injected AANs is very different from ingested aluminum.
Source: Vaccine Papers - Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990–1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except for the age of onset. This ALS “cluster” represents the second such ALS cluster described in the literature to date. Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide.
Source: US National Library of Medicine National Institutes of Health - ASIA: Autoimmune/inflammatory syndrome induced by adjuvants
In recent years, four conditions: siliconosis, the Gulf war syndrome (GWS), the macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena were linked with previous exposure to an adjuvant. Furthermore, these four diseases share a similar complex of signs and symptoms which further support a common denominator.Thus, we review herein the current data regarding the role of adjuvants in the pathogenesis of immune mediated diseases as well as the amassed data regarding each of these four conditions.
Source: The Zabludowicz Center for Autoimmune Diseases, Department of Medicine B' Sheba Medical Center, Tel-Hashomer, Israel - Shoenfeld's syndrome: Clinical and immunological spectrum
Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes post-vaccination phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis. This syndrome is characterized by nonspecific and specific manifestations of autoimmune disease. The main substances associated with ASIA are squalene (Gulf War syndrome), aluminum hydroxide (postvaccination phenomena, macrophagic myofasciitis) and silicone with siliconosis.
Source: Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico - Autoimmune/inflammatory syndrome induced by adjuvants: Unveiling the pathogenic, clinical and diagnostic aspects
In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by Adjuvants' was defined pointing to summarize for the first time the spectrum of immune-mediated diseases triggered by an adjuvant stimulus such as chronic exposure to silicone, tetramethylpentadecane, pristane, aluminum and other adjuvants, as well as infectious components, that also may have an adjuvant effect. All these environmental factors have been found to induce autoimmunity by themselves both in animal models and in humans: for instance, silicone was associated with siliconosis, aluminum hydroxide with post-vaccination phenomena and macrophagic myofasciitis syndrome.
Source: The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy - Autoimmune/inflammatory syndrome induced by adjuvants: Even and odd
Recently, Shoenfeld and Agmon-Levin described a potential new syndrome, namely ASIA - autoimmune/inflammatory syndrome induced by adjuvants, that comprises four medical conditions: siliconosis, the Gulf war syndrome, the macrophagic myofasciitis syndrome and post-vaccination phenomena, characterized by hyperactive immune responses accompanied by a similar complex of signs and symptoms. Most relevantly, these conditions share a linkage represented by adjuvants.
Source: Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Viale del Policlinico 155, Rome, Italy - Gulf War syndrome as a part of the autoimmune (autoinflammatory) syndrome induced by adjuvant (ASIA)
Recently, Shoenfeld et al. suggested that four conditions--siliconosis, macrophagic myofaciitis (MMF), GWS and post-vaccination phenomena--that share clinical and pathogenic resemblances, may be incorporated into common syndrome called 'Autoimmune (Autoinflammatory) Syndrome induced by Adjuvants' (ASIA). Symptoms and signs of the four conditions described by Shoenfeld et al. show that at least eight out of ten main symptoms are in correlation in all four conditions.
Source: The Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer, Israel - Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats
Higher aluminum (Al) content in infant formula and its effects on neonatal brain development are a cause for concern. This study aimed to evaluate the distribution and concentration of Al in neonatal rat brain following Al treatment, and oxidative stress in brain tissues induced by Al overload.
Source: Journal of Biomedical Science 2012 - Empirical data confirm Autism symptoms related to Aluminum and Acetaminophen exposure
Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database.
Source: Entropy Journal 2012 , 14 - How aluminum promotes hepatic and neurological diseases
Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes.
Source: Cell Biology and Toxicology April 2013, Volume 29, Issue 2 - A new autoimmunity syndrome linked to aluminum in vaccines
The biggest names in the field of study of the human immune system are attached to current papers in the most prestigious immunology literature that link widely used vaccine ingredients such as aluminum to terrifying modern epidemics of immune-mediated diseases including autism and Alzheimer's. As well, they've identified an entirely new post-vaccine syndrome: Autoimmune Inflammatory Syndrome Induced by Adjuvants (ASIA).
Source: GreenMedInfo.com - The Spectrum of ASIA
This patient’s story illustrates the acceleration of an autoimmune or immune-mediated condition following exposure to external stimuli. During the past year a new syndrome was introduced and termed ASIA [Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants]. This syndrome assembles a spectrum of immune-mediated diseases triggered by an adjuvant stimulus.
Source: Lupus (2012) 21 - Aluminium in vaccine-associated macrophagic myofasciitis and chronic fatigue syndrome
Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines. While a little is known of disease aetiology both conditions are characterised by an aberrant immune response, have a number of prominent symptoms in common and are coincident in many individuals.
Source: Birchall Centre for Inorganic Chemistry and Materials Science, Keele University, Staffordshire ST5 5BG, UK - Aluminum adjuvants and adverse events in subcutaneous allergy immunotherapy
There are very few data purporting to the safety of aluminium adjuvants in allergy immunotherapy and particularly so in relation to longer term health effects. There are, if only few, published reports of adverse events following allergy immunotherapy and aluminium adjuvants are the prime suspects in the majority of such incidents.
Source: Allergy, Asthma & Clinical Immunology Journal Vol. 10 - Aluminium neurotoxicity: Neurobehavioural and oxidative aspects
Aluminium is the most widely distributed metal in the environment and is extensively used in daily life that provides easy exposure to human beings. The exposure to this toxic metal occurs through air, food and water. However, there is no known physiological role for aluminium within the body and hence this metal may produce adverse physiological effects. Chronic exposure of animals to aluminium is associated with behavioural, neuropathological and neurochemical changes. Among them, deficits of learning and behavioural functions are most evident.
Source: Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India - Topological conformational changes of human papillomavirus (HPV) DNA bound to an insoluble aluminum salt
HPV DNA fragments were not only bound to Merck's proprietary aluminum adjuvant, but they had also adopted a non-B DNA conformation, thereby creating a novel chemical compound of unknown toxicity.
Source: Advances in Biological Chemistry, Vol.3 No.1, February 2013 - Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
Immune challenges during early development, including those vaccine-induced, can lead to permanent detrimental alterations of the brain and immune function. Experimental evidence also shows that simultaneous administration of as little as two to three immune adjuvants can overcome genetic resistance to autoimmunity.
Source: Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada and Departments of Ophthalmology and Visual Sciences and Experimental Medicine and the Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada - A Glimpse into the Scary World of Vaccine Adjuvants
Adjuvants are formulated compounds, which when combined with vaccine antigens intensify the body’s immune response. They are used to elicit an early, high and long-lasting immune response.
Source: Vaccine Choice Canada - Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except for the age of onset. This ALS "cluster" represents the second such ALS cluster described in the literature to date. Possible causes of GWS include several of the adjuvants in the anthrax vaccine and others. The most likely culprit appears to be aluminum hydroxide
Source: Departments of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada - Aluminum adjuvants, are they safe?
Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds.
Source: Current Medicinal Chemistry, 2011, 18, 2630-2637
